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Frontline Plus

Frontline Plus features

  • Kills fleas for at least one month
  • Controls and treats Flea Allergy Dermatitis
  • Kills all known ticks for at least one month
  • Water-resistant
  • Easy to administer spot-on application
  • Each tube contains Fipronil & S-Methoprene



From $32.95





Style Number: MSD14-CONFIG

Product Detail: Frontline Plus

Information about Frontline Plus

Frontline Plus provides protection against fleas and ticks, and contains a special ingredient to kill flea eggs and larvae. By stopping the development of new fleas, Frontline Plus provides the most complete flea and tick protection available. Frontline Plus kills 100% of fleas and ticks within 48 hours, including many ticks that transmit dangerous diseases that can affect other pets and humans.

Frontline Plus Flea Control has been formulated for use on puppies and kittens from eight weeks of age and is safe for use on pregnant and lactating animals. It is a water-resistant flea medication, so it continues to kill fleas even after shampooing, swimming, rain or exposure to sunlight.

Product Information Schedule

N.B. Pet Shed sells the Australian versions of the products listed below.
Metric conversion: 1 kg = 2.2 lbs

  Dosage Active Ingredients For cats
Frontline Plus for Cats (Green Box)      
Australian Version, NRA Approval No. 54524 0.5 mL 100 g/L Fipronil & 120 g/L (S)-Methoprene 8 weeks or older
USA Version, EPA Reg. No. 65331-4 0.017 fl oz (0.5 ml) 9.8% Fipronil & 11.8% (S)-Methoprene (by weight) 8 weeks or older
  Dosage Concentration For dogs weighing
Frontline Plus for Dogs (Orange Box)      
Australian Version, NRA Approval No. 54523 0.67 mL 100 g/L Fipronil & 90 g/L (S)-Methoprene Up to 10kg
USA Version, EPA Reg. No. 65331-5 0.023 fl oz (0.67 mL) 9.8% Fipronil & 8.8% (S)-Methoprene (by weight) Up to 22 lbs
Frontline Plus for Dogs (Blue Box)      
Australian Version, NRA Approval No. 54523 1.34 mL 100 g/L Fipronil & 90 g/L (S)-Methoprene 10-20 kg
USA Version, EPA Reg. No. 65331-5 0.045 fl oz (1.34 mL) 9.8% Fipronil & 8.8% (S)-Methoprene (by weight) 23-44 lbs
Frontline Plus for Dogs (Purple Box)      
Australian Version, NRA Approval No. 54523 2.68 mL 100 g/L Fipronil & 90 g/L (S)-Methoprene 20-40 kg
USA Version, EPA Reg. No. 65331-5 0.091 fl oz (2.68 mL) 9.8% Fipronil & 8.8% (S)-Methoprene (by weight) 45-88 lbs
Frontline Plus for Dogs (Red Box)      
Australian Version, NRA Approval No. 54523 4.02 mL 100 g/L Fipronil & 90 g/L (S)-Methoprene 40-60 kg
USA Version, EPA Reg. No. 65331-5 0.136 fl oz (4.02 mL) 9.8% Fipronil & 8.8% (S)-Methoprene (by weight) 89-132 lbs

Frontline Plus has been approved for sale in Australia by the APVMA. The US equivalent of this product has been approved for sale by the EPA.

Both the Australian and US products contain the same active ingredients, Fipronil & (S)-Methoprene.

However, the products sold by Pet Shed are sold in Australian packaging which has not been approved for sale in the US. As a consequence, the Australian packaging does not have EPA approval and the sale and purchase of products in the Australian packaging may be illegal in the US.

If swallowed call a poison control center or doctor immediately for treatment advice. For hazards to domestic animals the 24 hour assistance line within the U.S.A. is 1-800-660-1842.

The Product Information Schedule above indicates some of the material differences between the Australian and U.S.A. versions.

Ratings & Reviews

Based on 148 Review(s)

Average Rating


Ratings Overview











Most Recent Reviews

Jul 10, 2019


The Best Medicine Out on the Market!
Written by KDixon
May 15, 2019

I have been using Frontline Plus on all my animals for over 20 years. When I found Joe's website 10 years ago, I was elated! It has saved our family so much money. Thanks, Joe!

frontline plus for cats
Written by Marilyn
Apr 08, 2018

Been using Frontline for years on my cat. No fleas or ticks.! Ticks and fleas were really bad last year. Had several on us when we went walking but none on my cat. Really works great. Although she is inside most of the time she loves to be outside when it is warm. Frontline keeps those critters off.

Written by Bob
Nov 29, 2017

Used another product - dog appears to be allergic to it - going back to Frontline.
Written by khoff
Sep 26, 2017

great product! no fleas or ticks

Frontline Plus
Written by ladylobo0
Jul 05, 2017

I have used this product for over 10 years and it has never failed me. My cats and dogs love it and stand perfectly still for me to apply it every month. Being able to get it at such a great price is just awesome!

Frontline Plus
Written by Buddy and Munch
Jun 13, 2017

Our Dad has put these drops on us for years and we've never had to scratch for fleas or ticks. He also gives us yummy Heartguard Plus and we never have to worry about those critters. We love Dad! Buddy and Munch

Frontline Plus
Written by Vivian Phillips
Jun 07, 2017

I am very happy with the results of applying Frontline Plus to my 12 lb rat terrier. We live in an area with lots of deer ticks that transmite Lyme dissease and he has been healthy for his 10 years of life this far. I only apply Frontline Plus every two months. My dog also receives at the vet's office the Lyme dissease vacine once a year in the spring. Frontline Plus costs a little more than othe similar products but I will not change it. I save money by ordering Frontline Plus on line to Joe's Pet Meds, and it always arrives.
Written by Patricia
May 08, 2017

I have been using Joe's Pet Meds for 11 years and they have the cheapest and best Frontline Plus Prices......I would recommend them to anyone and do to all the people that adopt mini Dachshunds from me. Thanks Joe's Pet Meds.
Written by Cyberfrance
Apr 07, 2017

I have 6 smaller dogs and I've been using both Frontline Plus and the generic for about 10 years. I find that if I buy in the largest size, I can split the dosage among all 6 dogs. They have never had a flea among them. I live in Maryland in the USA and it's hot here in summer. Fleas can be a real problem. I highly recommend Frontline Plus and the generic. They work. If you have a severe flea problem, it is wise to first have your dogs bathed before you apply the liquid. I also have my dog yard treated for fleas with Sevin powder in the spring. So far, so good. You will save a lot of money if you purchase your dog supplies here. I have been doing so for MANY years. I recommend them all of the time.